Analysis on Gene Polymorphism of UGT1A1 Gene Promoter in Patients with Malignant Tumour
10.3969/j.issn.1671-7414.2015.03.010
- VernacularTitle:恶性肿瘤患者 UGT1A1基因启动子多态性检测结果分析
- Author:
Zegang WU
;
Yan LI
;
Hongyun ZHENG
;
Ge XIONG
- Publication Type:Journal Article
- Keywords:
UGT1A1 gene;
gene sequencing;
polymorphism;
irinotecan
- From:
Journal of Modern Laboratory Medicine
2015;(3):35-37,42
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect UGT1A1 gene promoter polymorphism with gene sequence method and analyze the distribu-tion of UGT1A1*28 and UGT1A1*6 gene polymorphism in Wuhan.Methods A total of 230 samples were collected from tumor patient in Medical Oncology Department of Renmin Hospital of Wuhan University from January 2013 to December 2014,then gene sequence of the target fragments were detected by Sanger sequencing method and analyzed patient UGT1A1 gene promoter polymorphism TA box.Results In this research examination 230 example tumor patient,198 patients (86.1%)were identified with TA6/TA6 genotype,29 patients (12.6%)were identified with TA6/TA7 genotype,3 pa-tients (1.3%)TA7/TA7 variant.Conclusion TA6/TA6 wild-typewas higher frequence in patients with malignant tumour in Wuhan.
