Values of Procalcitonin Level in Serum for Predicting Gram-negative Bacteremia

VernacularTitle:血清降钙素原水平预示革兰阴性菌血症的价值评估
Author: Yunshuang LIU
Publication Type:Journal Article
Keywords: procalcitonin; Gram-negative bacteria; bacteremia
From: Journal of Modern Laboratory Medicine 2015;(2):77-79,83
CountryChina
Language:Chinese
Abstract: Objective To evaluate the values of procalcitonin (PCT)level in serum for predicting Gram-negative bacteremia (GNB).Methods Among 499 candidates for study entry,314 were GN bacteraemia,and 185 were Gram-positive bacterae-mia (GPB).The serum PCT level were measured in 499 candidates.Results PCT levels were found to be markedly higher in patients with GNB (median=5.16,0.02~450.10 ng/ml)than in those with GPB (median=0.38,0.02~44.70ng/ml) (P =0.000).The percentage of GNB were increased along with PCT level.The proportion of GNB was 100% when PCT ≥45.0 ng/ml.For prediction of GNB a PCT level of 6.00 ng/ml had a sensitivity of 49.4% and specificity of 85.2% and posi-tive predictive value of 85.6% and negative predictive value of 50.0%,respectively.The area under the receiver operating characteristic curve for discriminating GNB and GPB was 0.714,confidence interval of 95% was 0.672 ~ 0.753,SE =0.0229,P <0.0001.Conclusion PCT is an early and reliable indicator for predicting GNB.