Effects of Manganese Superoxide Dismutase 9 Ala/Val Genetic Polymorphisms on Coronary Heart Disease

VernacularTitle:锰超氧化物歧化酶9 Ala／Val 基因多态性对冠心病的影响
Author: Chuangli YAO ; Jia ZHAO ; Yang LI ; Bo LI ; Hua LU ; Ni BAI ; Lin LIU ; Weichuan XIN ; Xiaojian JIANG
Publication Type:Journal Article
Keywords: manganese superoxide dismutase (Mn-SOD); coronary heart disease (CHD); genetic polymorphism
From: Journal of Modern Laboratory Medicine 2015;(2):1-2,6
CountryChina
Language:Chinese
Abstract: Objective To study associations between manganese superoxide dismutase 9 Ala/Val (Mn-SOD 9 Ala/Val)genet-ic polymorphism and total superoxide dismutase (T-SOD)and Mn-SOD activity and the impact on coronary heart disease (CHD)were studied.Methods There were 82 CHD patients and 57 controls in this research.Sequencer was used to identify the genotype of Mn-SOD 9 Ala/Val genetic polymorphism and colorimeter was used to detect the serum T-SOD and Mn-SOD activity.Results Compared with the control group,the serum T-SOD and Mn-SOD activity of the CHD group was significantly reduced(t=4.83,6.57,P all<0.05),while the VV genotype and V allele of Mn-SOD 9 Ala/Val genetic poly-morphism of the CHD group were higher (χ2 =4.75,P <0.05).The serum T-SOD and Mn-SOD activity of the Mn-SOD 9 VV genotype was significantly lower than the Mn-SOD 9 AA genotype(t=2.96,3.11,P all<0.05).Conclusion The ser-um T-SOD and Mn-SOD activity in the CHD patients was reduced.Mn-SOD 9 Ala/Val genetic polymorphism was involved in the pathogenesis of CHD by influencing the Mn-SOD activity.