Clinical Values of Blood Serum Concentration of MHD in Children with Epilepsy of Different Ages

VernacularTitle:不同年龄阶段癫痫患儿奥卡西平活性代谢产物血药浓度的临床价值
Author: Xia LI ; Xiaohong LIU ; Le YANG
Publication Type:Journal Article
Keywords: oxcarbazepine; metabolite; serum concentration; epilepsy; age
From: Journal of Modern Laboratory Medicine 2015;(1):143-144,148
CountryChina
Language:Chinese
Abstract: Objective To investigate effects of blood serum concentration of MHD in children with epilepsy of different ages. Methods Two hundred children with epile psy were divided into four groups according to age,group A:<3 years old in-fants;group B:3~6 years old preschoolers;group C:7~13 years old school-age chidren.Group D:14~18 years old adoles-cents,each group had 50 chidren.The serum concentration of active metabolite was detected by high-perform ance liquid chromatography (HPLC)method.Results The serum concentration of MHD increase with age,but there were no statistical significance (P>0.05).Conclusion The indiv idual variation in blood serum concentrations of MHD in children with epi-lepsy adminisered with oxcarbazepine is high,therefore monitoring the blood serum concentration is helpful to adj ust the dose of medication and to promote the implementation of the individualized dosing regimens.