Clinical Significance of Plasma D-dimer in Systemic Sclerosis

VernacularTitle:系统性硬化病患者血浆D-dimer的临床意义探讨
Author: Fang HAN ; Xiaofang HU ; Dongya MENG ; Wei ZHENG ; Lu WANG ; Nan WAN
Publication Type:Journal Article
Keywords: systemic sclerosis; D-dimer; pulmonary artery hypertension
From: Journal of Modern Laboratory Medicine 2015;(1):132-133,136
CountryChina
Language:Chinese
Abstract: Objective To study correlation between systemic sclerosis(SSc)and plasma D-dimer and to reveal the probably rules of the fibrinolytic systems in SSc.Methods In 2013 January to 2014 January,cellected 32 patients with SSc and 35 with healthy controls to detected level of plasma D-dimer.Logistic and t student test were used for statistical analysis for correlation between SSc and pulmonary artery hypertension.Results When compared to healthy controls (0.28±0.04μg/ml),the level of plasma D-dimer were significantly increased in SSc patient (0.31±0.05μg/ml,t=1.997,P=0.008).After stratifying SSc patients according to disease subset,whereas patients with diffuse subset displayed substantially increased values (0.41±0.06μg/ml,t=2.051,P<0.001).The level of plasma D-dimer was associated with pulmonary artery hyper-tension (OR=4.38,95%CI=2.59~8.91,P=0.008).Conclusion Demonstrated that SSc patients with diffuse subset are characterized by increased plasma D-dimer values,reflecting a potential activation of fibrinolytic cascaded,which might finally predispose these patients to thrombotic complications and pulmonary artery hypertension.