Establishment of Pepsinogen Reference Range and Its Clinical Application in Shanghai Area
10.3969/j.issn.1671-7414.2015.01.035
- VernacularTitle:上海地区胃蛋白酶原参考值的建立及临床应用
- Author:
Chunxing LIU
- Publication Type:Journal Article
- Keywords:
latex-enhanced immunoturbidimetry;
pepsinogen;
reference range
- From:
Journal of Modern Laboratory Medicine
2015;(1):121-122,125
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish serum pepsinogen (PG)reference range healthy crowd with latex-enhanced immunoturbi-dimetry of and explore its clinical application in stomach disease in Shanghai area.Methods Selected randomly 8 763 healthy adults who livied in Shanghai for more than 10 years and 269 patients with different stomach trouble confirmed by gastro-scope and pathology.By latex-enhanced immunoturbidimetry to detect the serum pepsinogen Ⅰ (PGⅠ)and pepsinogen Ⅱ(PGⅡ).Results The serum PGⅠ,PGⅡand PGⅠ/PGⅡlevel showed a skew distribution.The normal reference range was 24.6~98.97 ng/ml,≤21.7 ng/ml and ≥3.43.PGⅠand PGR values decreased significantly in both atrophic gastritis (PGⅠ=36.6 ng/ml,P=0.007,PGR=3.63,P<0.001)and gastric cancer groups(PGⅠ=20.6 ng/ml,PGR=3.2,P<0.001).PGⅠand PGⅡvalues increased significantly in digestive ulcer group(PGⅠ=83.6 ng/ml,PGⅡ=17.5 ng/ml,P<0.001),but PGR values decreased significantly (PGR=4.37,P=0.006).Conclusion Establishing serum pepsinogen refer-ence range of healthy crowd with latex-enhanced immunoturbidimetry in the Shanghai area can help to diagnose better the stomach trouble.