Study on the Relationship between Severity of Coronary Artery Lesion and the Level Cystatin C,Nitric Oxide and Superoxide Dismutase of Serum
10.3969/j.issn.1671-7414.2015.01.022
- VernacularTitle:冠状动脉病变程度与血清胱抑素、一氧化氮及超氧化物歧化酶水平的相关性研究
- Author:
Yunfeng SHEN
;
Yuangui HU
;
Hongbo ZHANG
;
Qiang TIAN
- Publication Type:Journal Article
- Keywords:
CyC;
NO;
SOD;
coronary artery lesion
- From:
Journal of Modern Laboratory Medicine
2015;(1):82-84,87
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation between coronary lesion and Cystatin C (CyC),Nitric Oxide (NO)and Super oxide dismutase,accumulate the clinical experience in prevention and diagnose of Coronary Heart Disease (CHD)by analy-zing the contents of serum Cystatin C (CyC),Nitric Oxide and Superoxide Dismutase in patients with coronary lesion.Meth-ods According to their severity of coronary artery lesion,all cases were divided into four groups:Normal compared group (40 cases);Simple branch pathological group (44 cases);Double branch pathological group (43 cases):Multi-branch patho-logical group (35 cases).All cases were tested CyC,NO,SOD and hs-CRP in serum.Results The level of CyC and hs-CRP were increased gradually from normal group to multi-branch group.The level of NO and SOD were decreased gradually from normal group to multi-branch group.There were significant differences the levels of CyC,NO,SOD and hs-CRP among the four groups.Coronary lesion Gensini in the CHD patients had significant positive relationship to the level of CyC or hs-CRP respectively (r=0.473,0.429),had significant negative relationship to the level of NO or SOD respectively (r=-0.356, 0.384)(P<0.05).CyC in the CHD patients had significant positive relationship to the level of hs-CRP (r=0.458),had sig-nificant negative relationship to the level of NO or SOD respectively (r=-0.426,0.484,P<0.05).Conclusion By aggra-vation of coronary artery lesion,the level of CyC increased,reduced the contents of NO,SOD,aroused endothelial dysfunc-tion,induced occurrence and aggravation of coronary artery lesion.CyC,NO and SOD play important mark in the assistant diagnosis of the disease.
