Diagnostic Value of Osteopontin for Ovarian Cancer:a Meta-Analysis

VernacularTitle:血清骨桥蛋白诊断卵巢癌的meta分析
Author: Xiaochun HUANG ; Xiaobing SUN ; Zhide HU ; Yi SUN ; Anmei DENG ; Rongrong ZHU ; Lei ZHANG
Publication Type:Journal Article
Keywords: ovarian cancer; osteopontin; diagnosis; meta analysis
From: Journal of Modern Laboratory Medicine 2014;(6):44-46,47
CountryChina
Language:Chinese
Abstract: Objective To evaluate the diagnostic performance of osteopontin (OPN)for ovarian cancer.Methods Wanfang, CQVIP and CNKI were retrieved to identify eligible studies on diagnostic value of OPN for ovarian cancer that published be-fore May,2014.The quality of the studies was evaluated by QUADAS tools.The diagnostic sensitivity,specificity,negative and positive likelihood ratios and diagnostic odds ratio (DOR)were pooled by random-effects models.The overall diagnostic performance was estimated by summary receiver operating characteristic (SROC)curves approaches.Results Six studies met the included criteria.The summary estimates for OPN in the diagnosis of ovarian cancer in the studies included were as follows:sensitivity 0.83 [(95% confidence interval(CI):0.78~0.87)],specificity 0.91 (95% CI,0.88~0.94),positive likelihood ratio 9.00 (95% CI,5.91~13.71),negative likelihood ratio 0.19 (95% CI,0.15~0.25),and DOR 47.58 (95%CI,27.93~81.05).The area under curve (AUC)for OPN was 0.87 with Q value of 0.80.Conclusion OPN has high diag-nostic value for ovarian cancer.