Analysis of Serum TSH and TH Level Changes in the First Trimester of Pregnancy
10.3969/j.issn.1671-7414.2014.05.041
- VernacularTitle:血清TSH，TH水平在妊娠早期的变化分析
- Author:
Fangqin LI
;
Yantao FENG
- Publication Type:Journal Article
- Keywords:
the first trimester of pregnancy;
thyroid stimulating hormone;
thyroid hormone
- From:
Journal of Modern Laboratory Medicine
2014;(5):147-148,151
- CountryChina
- Language:Chinese
-
Abstract:
Objective To provide the theoretical basis for clinical diagnosis and treatment of the related diseases by the com-parative analysis of serum thyroid stimulating hormone (TSH)and thyroid hormone (TH)[three iodine thyroid glycine (T3),thyroxine (T4),three free iodine thyroid former glycine (FT3)and free thyroxine (FT4)]levels between early preg-nant women and non-pregnant healthy women of childbearing age.Method Examined in the outpatient department of Yan’ an University Affiliated Hospital during 2013 November~2014 March,171 healthy women in 4~13 weeks of pregnancy were regarded as the observation group.In addition,149 non pregnant healthy women of childbearing age were regarded as the control group,who got physical examination in the hospital.The inclusion criteria were:no thyroid diseases history;no living history in local thyroid tumorarea;excluding the abnormal functionof thyroid diseases after history investigation and relevant examination.The detection method of serum TSH,T3,T4,FT3 and FT4 was the direct chemiluminescence assay. With reference of serum TSH and TH levels of the non-pregnant healthy women of childbearing age,the change of serum TSH and TH levels of early pregnant women was observed.Results Comparing the two groups,the pregnant women’s TSH level [1.97(1.17~2.65)mU/L],the non-pregnant women’s TSH level [2.42(1.73~3.58)mU/L],the difference was statistically significant (P<0.01).The pregnant women’s serum T3 level [1.94(1.58~2.37)nmol/L]and T4 level [131.00 (111.60~147.80)nmol/L],the non-pregnant women’s T3 level [1.55 (1.37~1.86)nmol/L]and T4 level [109.30(94.95~122.90)nmol/L],the difference was statistically significant (P<0.01).The pregnant women’s serum FT3 level [4.73(4.44~4.94)pmol/L]and FT4 level [14.88(13.83~16.33)pmol/L],the non-pregnant women’s FT3 lev-el [4.70(4.37~5.01)pmol/L]and FT4 level [15.06(13.54~17.35)pmol/L],they have no significant difference (P>0.05).Conclusion Serum TSH and TH levels of women in the first trimester of pregnancy have different degrees of chan-ges.Therefore,thyroid function testing is necessary for pregnant women during childbirth examination.It can avoid the women and offspring from negative influence of pregnancy women with abnormal thyroid function and achieve the goal of eu-genics.
