Investigation on related factors of CD 34+ cells in peripheral blood mobilization effect by G-SCF stimulation
10.3969/j.issn.1673-4130.2015.07.003
- VernacularTitle:经粒系集落刺激因子刺激外周血CD34＋细胞动员效果相关因素的考察
- Author:
Li WEI
;
Wei WU
;
Lanjuan LI
;
Chaojun WANG
- Publication Type:Journal Article
- Keywords:
hematopoietic stem cells;
peripheral Blood;
granulocyte colony-stimulating-factors;
CD34+cells
- From:
International Journal of Laboratory Medicine
2015;(7):870-871,874
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence factors of peripheral blood hematopoietic stem cell of healthy donor by granu‐locyte colony‐stimulating‐factors(G‐CSF) mobilization .Methods G‐CSF was subcutaneously injected in 24 cases of healthy donor for mobilizing hematopoietic stem cells .The T lymphocyte subgroup and blood routine data were detected .Results After G‐CSF stimulation ,peripheral blood CD3+ (% ) ,CD3+CD4+ (% ) ,white blood cell (WBC) count and platelet were significantly increased (P<0 .05) .And nucleated cells density of bone ,percentage of CD34+ cells on mobilized 4 ,5 ,6 d had no obvious difference .The correlation analysis showed that gender ,age and weight were negatively correlated with CD 34+cells percentage (P<0 .05) and pos‐itively correlated with WBC count (P<0 .01) .Conclusion Male donor is superior to female donor within a certain range ,the smal‐ler age ,the lighter weight ,the higher WBC count ,the higher the percentage of CD34+ cells in peripheral blood hematopoietic stem cells after G‐CSF mobilization .
