Rapid Identification and Determination of Gatifloxacin Injections by Raman Spectroscopy
- VernacularTitle:拉曼光谱快速检测加替沙星注射液
- Author:
Ping LI
;
Yan ZHANG
- Publication Type:Journal Article
- Keywords:
Gatifloxacininjections;
Ramanspectroscopy;
Rapididentificationanddetermination;
Identification;
Contentdeter-mination
- From:
China Pharmacist
2014;(10):1626-1628,1648
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To develop a method for the rapid identification and determination of gatifloxacin injections by Raman spec-troscopy. Methods:Raman spectroscopy was used as the method of identifying and determining gatifloxacin injections. The determina-tion conditions were as follows:a micro Raman spectroscopy, excitation wavelength:785nm, objective lens:50X, laser power:3mW, signal acquisition time:60s. Results:The result showed that the Raman spectroscopy could identify and determine gatifloxacin injec-tions, the content of gatifloxacin in the injections was respectively 99. 49%,97. 56% and 100. 2%(Specification:10ml∶0. 2g), and 97. 75%, 94. 58% and 96. 25%(Specification:2ml∶0. 1g), and there was no significant difference between the above determination results and the results from the HPLC method by t-test. Conclusion:For the fast and nondestructive properties, the presented method can be developed as an analysis method for gatifloxacin injections.
