Preparation and in vitro Drug Release of Betahistine Dihydrochloride Sustained-release Matrix Tablets
- VernacularTitle:盐酸倍他司汀缓释骨架片的制备及体外释药特性研究
- Author:
Kai LI
;
Ying CHEN
;
Jun CHAI
;
Yun XIONG
;
Jiao XIONG
- Publication Type:Journal Article
- Keywords:
Betahistinedihydrochloride;
Sustained-releasematrixtablets;
Preparation;
invitrodrugrelease
- From:
China Pharmacist
2014;(10):1665-1668,1669
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To prepare betahistine dihydrochloride sustained-release matrix tablets. Methods: The tablets were pre-pared with water soluble HPMC matrix, and the release behaviors were investigated by single factor study. The formula and preparation procedures were optimized by orthogonal design. Results:The optimal technology was as follows:using 60% HPMC K15M as the ma-trix material, calcium hydrogen phosphate as the filler, 10% PVP in 90% alcohol as the bonding agent;wet granulation compression technique was used to prepare the tablets with the tablet weight of 500mg. The in vitro drug release fits a Higuchi equation and the drug can be sustained-released within 12 h. Conclusion:The preparation technology is simple and the tablets have sustainol release behav-ior.
