Role of sphingosine-1-phosphate receptor 1 in pain modulation
10.3969/j.issn.1001-1978.2015.06.004
- VernacularTitle:鞘氨醇-1-磷酸受体1在疼痛中的作用研究
- Author:
Jinlu HUANG
;
Lili WAN
;
Cheng GUO
- Publication Type:Journal Article
- Keywords:
pain;
nervous system;
sphingosine-1-phosphate re-ceptor 1;
G protein-coupled receptor;
sphingosine-1-phosphate;
FTY720;
agonist
- From:
Chinese Pharmacological Bulletin
2015;(6):755-758,759
- CountryChina
- Language:Chinese
-
Abstract:
Sphingosine-1-phosphate receptor 1(S1PR1) is a new member of G protein-coupled receptor family. A great body of data suggest S1PR1 is capable of regulating lots of downstream signaling molecules and cellular processes. It is found that S1P/S1PR1 plays an important role in the development and mainte-nance of pain. However, it is controversial whether activation of S1PR1 would enhance or attenuate pain. Here, recent studies ＜br> and current perspectives are discussed in order to better under-stand the biological and pathological roles of S1PR1 in pain mod-ulation.
