The Expression and Clinical Significance of Histamine Receptors in Urinary Bladder in Patients with Ketamine-induced Cystitis
10.3969/j.issn.0253-9896.2013.10.006
- VernacularTitle:K粉相关性膀胱炎患者膀胱组织中组胺受体的表达及临床意义
- Author:
Liangzhen ZHU
;
Yonggang YU
;
Songbai LIAO
;
Gang LIU
;
Guantian YU
;
Yingjie WU
- Publication Type:Journal Article
- Keywords:
ketamine;
cystitis;
receptors,histamine;
mast cells;
immunohistochemistry
- From:
Tianjin Medical Journal
2013;(10):965-967,1043
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and clinical significance of four histamine receptors:H1R, H2R, H3R and H4R in urinary bladder of patients with ketamine-induced cystitis. Methods Immunohistochemical S-P method was used to detect the expression levels of histamine receptors:H1R, H2R, H3R and H4R in bladder tissues of 10 patients with ketamine-induced cystitis (experimental group) and distal tissue away from bladder tumors of 10 patients with cystectomy (control group). The average optical density (OD) values of four kinds of different histamine receptors were separately calcu-lated by Imagepro-plus 6.0 in two groups. At the same time, mast cells were marked by toluidine blue special dyeing and were counted. Results Comparing with control group, the expression levels of H1R, H2R, and H4R were significantly in-creased in experimental group (P＜0.05). Mast cells diffused interstitial bladder infiltrates (P＜0.05). There was no signifi-cant difference in the expression of H3R in two groups. Conclusion Mast cells, H1R, H2R, and H4R are closely related to the ketamine-induced cystitis, which may be new diagnostic indicators and new treatment targets of ketamine-induced cysti-tis.
