Effect of Yixintai granule on myocardial remodeling in rabbits with chronic heart failure
10.3760/cma.j.issn.1008-1372.2015.03.006
- VernacularTitle:益心泰颗粒对慢性心力衰竭兔心肌重构的影响
- Author:
Zhihua GUO
;
Ya LI
;
Gangqiang WU
;
Yun TANG
;
Xiangping MAO
;
Yueai WANG
;
Tao SUN
- Publication Type:Journal Article
- Keywords:
Heart failure/PA/ZD;
Ventricular remodeling/DE;
CARDIOVASCULAR AGENTS ( TCD)/AD
- From:
Journal of Chinese Physician
2015;(3):340-342,346
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of Yixintai granule on myocardial remodeling in rabbits with chronic heart failure ( CHF) .Methods The rabbit model of CHF with adriamycin was established. These successful CHF models of rabbits were divided into model group, high,middle, and low dose of Yix-intai groups, losartan potassium group, and normal control group.Echocardiographic indexes and myocardi-al remodeling indexes were measured after 4 weeks of medication.Results Compared to the model group, the left ventricular posterior wall (LVPW), left ventricular internal diameter at end-systole (LVIDs), left ventricular internal diameter at end-diastole ( LVIDd) , cardiac index ( CI) , and left ventricular mass index (LVWI) of the treatment groups were decreased ( P <0.05 or P <0.01), and the interventricular septum ( IVS) of the middle and high Yixintai groups was decreased significantly ( P <0.01 ) .Compared to the low dose of Yixintai group, the IVS, LVPW, CI, and LVWI of the middle and high Yixintai groups were decreased ( P <0.05 or P <0.01) , and the LVIDs and LVIDd of the high Yixintai group were decreased ( P <0.05 ) .Conclusions Yixintai granule can improve myocardial remodeling in rabbits with CHF. Meanwhile, the curative effect of medial and high groups of Yixintai is better than the low dose group.
