Relationship between the expressions of PI3K and regional angiogenesis,invasion,metastasis,and prognosis in cervical squamous cell carcinoma
10.3969/j.issn.1673-4130.2015.14.009
- VernacularTitle:PI3K 表达与宫颈鳞状细胞癌局部血管生成和浸润转移及预后的关系
- Author:
Zhaodong LIU
;
Zhongqing JIANG
;
Liyu DAI
- Publication Type:Journal Article
- Keywords:
Cervical Squamous Cell Carcinoma;
PI3K;
proliferation index;
microvessel density;
tumor metastasis;
im-munohistochemistry
- From:
International Journal of Laboratory Medicine
2015;(14):1977-1978,1981
- CountryChina
- Language:Chinese
-
Abstract:
Objective The expressions of PI3K in invasive squamous cell carcinoma of cervix and their clinical significance were investigated .Methods The expressions of PI3K ,Ki‐67 and CD34 protein in 28 cases of normal cervical epithelium (NCE) ,36 cases of cervical intraepithelial neoplasm (CIN) and 68 cases of squamous cell carcinoma of cervix (SCC) were detected by immunohisto‐chemistry SP method .Results The positive expression rates of PI3K in NCE ,CIN and SCC were 25 .00% ,55 .56% and 85 .29% , respectively .The positive expression rates of PI3K increased remarkably from NCE and CIN to SCC(P<0 .05) .The expression of PI3K in SCC was significantly positive correlated with PI and MVD .The expression of PI3K in SCC was related with FIGO stag‐ing ,histological grading and pelvic lymph node metastasis (P<0 .05) ,but was not related with age ,depth of stroma infiltration and intravascular infiltration (P>0 .05) .In the cases with FIGO staging Ⅱ ,poorly differentiated tissue and pelvic lymph node metasta‐sis ,The positive expression rate of PI3K significantly higher than those in the cases without them(P<0 .05) .Conclusion The o‐ver‐expression of PI3K may lead to up regulation of tumor angiogenesis and cancer cell proliferation in SCC ,and may promote tumor Metastasis and progress of SCC .
