Genetic evolution and heterogeneity of multiple myeloma: a report from the 2013 EHA annual meeting

VernacularTitle:多发性骨髓瘤遗传学演化及克隆异质性研究进展:2013年欧洲血液学会年会报道
Author: Huixing ZHOU ; Wenming CHEN
Publication Type:Journal Article
Keywords: Multiple myeloma; Monoclonal gammopathy of undetermined significance; Smoldering multiple myeloma; Genetic heterogeneity; Target therapy; EHA annual meeting
From: Journal of Leukemia & Lymphoma 2013;22(8):449-450,455
CountryChina
Language:Chinese
Abstract: Recent studies have shown that multiple myeloma (MM) is preceded by a premalignant state called monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM).Some of the genetic changes of MM are also present in MGUS and SMM,including chromosomal translocations,copy number changes,somatic mutations and so on.This article discusses the genetic heterogeneity.