Analysis of the risk factors of central nervous system complications after allogeneic hematopoictic stem cell transplantation
10.3760/cma.j.issn.1009-9921.2012.11.008
- VernacularTitle:异基因造血干细胞移植的中枢神经系统并发症危险因素分析
- Author:
Lijie HAN
;
Hongxia MA
;
Xiujuan DONG
;
Xianjing WANG
;
Xueli JIAO
;
Lei CHEN
;
Xiaowu ZHAO
- Publication Type:Journal Article
- Keywords:
Hematopoietic stem cell transplantation;
Central nervous system;
Complications
- From:
Journal of Leukemia & Lymphoma
2012;21(11):671-673,677
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyse the etiology,clinical characteristics and risk factors of central nervous system (CNS) complications after allogeneic hematopoietic stem cell transplantation (allo-HSCT).Methods The clinical features of CNS complications in patients who underwent allo-HSCT were observed,and analysis its causes and risk factors.Results 8 cases of CNS complications occured in 69 patients within 6 months after allo-HSCT and the incidence was 11.6 ％,the occurrence rate of CNS complications was 21.4 ％ (6/28) in HLA mismatched group,higher than HLA matehed group [49 ％ (2/41)] (P ＜ 0.05).Analogously,the incidence was 44.4 ％ (4/60) in patients with graft-versus-host disease (GVIID) (＞grade 2),which was significantly higher than patients with 2 or below grade 2 GVHD [6.7 ％ (4/9)] (P ＜ 0.01).But there was no significant difference in the incidence of CNS complications between ≤14 years old and ＞14 years old,with or without ATG,different stages of diseases,whether pretreatment with maryland respectively (P ＞0.05),either.Epilepsy and intracranial infection were the most common CNS complications in allo-HSCT,followed by intracranial hemorrhage.Conclusion HLA mismatched and above grade 2 GVHD are the risk factors of CNS complications in allo-HSCT.Epilepsy,intracranial infection and bleeding are common CNS complications in allo-HSCT.
