Effects of fluoxetine combined with small doses of aripiprazole in treatment of post stroke depression and its influence on neural functional recovery
10.3760/cma.j.issn.1008-6706.2015.07.034
- VernacularTitle:氟西汀联合小剂量阿立哌唑对脑卒中后抑郁的疗效及对神经功能恢复的影响
- Author:
Fanzhen MENG
;
Xiaoyan LU
;
Shengxian LI
- Publication Type:Journal Article
- Keywords:
Cerebral applexy;
depression;
Aripiprazole;
Fluoxetine
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(7):1060-1061,1062
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effects of fluoxetine combined with small doses of aripiprazole in treatment of post -stroke depression and the influence on the recovery of neurological function. Methods 74 patients with post stroke depression were randomly divided into the two groups,all patients were given routine comprehensive treatment,the control group treated with fluoxetine,while the observation group was treated with fluoxetine combined with small doses of aripiprazole,clinical curative effect,neurological deficits and activities of daily living of the two groups were compared.Results The total effective rate of the observation group was 94.59%,which was significantly higher than 78.38% of the control group (χ2 =9.78,P<0.05);NIHSS scores of the observation group at the end of 4 week and 8 week of treatment were (10.85 ±1.22)and (6.03 ±0.78),which significantly reduced than that of the control group(t=6.18,6.62,all P<0.05 );Barthel index of the observation at the end of 4 weeks and 8 weeks of treatment were (49.56 ±4.68)and (67.43 ±4.75),which significantly increased than that of the control group(t=6.63,7.00,all P<0.05);The incidence of adverse reactions of the two groups had no signif-icantly different(χ2 =2.38,P>0.05).Conclusion Fluoxetine combined with small dose of aripiprazole has an ex-act effect in the treatment of post stroke depression,with high security.
