The protective effects of mild hypothermia on cerebral and levels of serum levels of anti-brain antibodies after severe traumatic brain injury
10.3760/cma.j.issn.1008-6706.2015.07.028
- VernacularTitle:重型颅脑损伤后患者血清抗脑抗体水平变化及亚低温对脑保护作用的研究
- Author:
Cheng ZHAO
;
Guisheng DU
;
Benchao ZHANG
;
Mingyang WANG
- Publication Type:Journal Article
- Keywords:
Craniocerebral trauma;
Anti-brain antibodies;
Hypothermia
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(7):1044-1045,1046
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the protective effects of mild hypothermia on cerebral and levels of serum levels of anti -brain antibodies after severe traumatic brain injury.Methods Severe traumatic brain injury were selected as the Ⅰ group (n=60),also select healthy as the Ⅱgroup (n=30),the Ⅰgroup was divided into group A (n=30)and group B (n=30)according to a random number table.The patients of group A was given hypothermia and the patients of group B were treated with temperature treatment,the levels of anti-brain antibodies in serum of each group were determined in ELISA assay,changes in cerebral blood flow before and after treatment of group A and group B were observed in Doppler,and observed Glasgow Outcome Score (GOS )of group A and group B.Results The level of anti-brain antibodies in serum of theⅠgroup was (0.59 ±0.02)U/mL significantly higher than that ofⅡ group (0.38 ±0.01)U/mL,the difference was statistically significant(t=9.192,P=0.029);the level of anti-brain antibodies in serum after treatment of group A was (1.58 ±0.03)U/ml significantly lower than that of group B (1.82 ±0.04)U/mL,the difference was statistically significant(t=10.042,P=0.019);the average flow velocity, pulse index and GCS score after treatment of group A were (54.20 ±0.23)cm/s,(0.51 ±0.02),(10.03 ±1.03) points significantly better than those of group B[(40.03 ±0.04)cm/s,(0.72 ±0.02),(8.12 ±0.02)points],the difference was statistically significant (t=9.892,10.041,9.189,P=0.021,0.018,0.026).Conclusion The lev-els of anti-brain antibodies in serum can significantly increase after severe traumatic brain injury,Hypothermia can reduce the serum levels of anti-brain antibodies,can increase cerebral blood flow.
