One case of interdigitating dendritic cell sarcoma concurrent with acute myelomonocytic leukemia and literatures review

VernacularTitle:急性粒-单核细胞白血病合并指状突树突细胞肉瘤一例并文献复习
Author: Yizhi JIANG ; Shengli XUE ; Ningzheng DONG ; Depei WU
Publication Type:Journal Article
Keywords: Interdigitating dendritic cell sarcoma; Leukemia,myelomonocytic,acute; Neoplasms,second primary
From: Journal of Leukemia & Lymphoma 2012;21(11):654-658,667
CountryChina
Language:Chinese
Abstract: Objective To summarize and learn the biological properties and clinical features of interdigitating dendritic cell sarcomas (IDCS).Methods The first IDCS patient concurrent with acute myelomonocytic leukemia (AML-M4) described herein,to our knowledge,was studied and 62 IDCS cases reported previously in the literature were reviewed.Results The patient had a history of breast cancer as well as radiotherapy and chemotherapy of it,and the patient showed poor response to 4 cycles of sequential chemocherapy regimens.Based on the laboratory results,IDCS and AML-M4 in this patient were both of myelogenous origination.Furthermore,review of the 62 IDCS patients reported previously showed that as high as 17 ％ of the patients had malignant disease and received radiotherapy or chemotherapy before they got IDCS,and patients of this group had worse prognosis compared with counterpart.Conclusion IDCS has poor prognosis,and therapy-related type worse.Prophylactic measures and stringent screening of the second cancer in those who received chemoterapy or radiotherapy are appropriated and necessary.