Efficacy of radiotherapy on nasal natural killer/T-cell lymphoma and prognostic analysis
10.3760/cma.j.issn.1009-9921.2011.03.011
- VernacularTitle:鼻腔自然杀伤/T细胞淋巴瘤放射治疗的疗效和影响因素
- Author:
Tao REN
;
Bangxian TAN
;
Mi LIU
;
Daiyuan MA
;
Yeqin ZHOU
;
Xiaohong SHU
;
Ji ZHOU
- Publication Type:Journal Article
- Keywords:
Nasal cavity;
Lymphoma,NK/T-cell;
Prognosis;
Radiotherapy
- From:
Journal of Leukemia & Lymphoma
2011;20(3):165-167,171
- CountryChina
- Language:Chinese
-
Abstract:
Objective To retrospectively analyze the efficacy of radiotherapy on nasal NK/T-cell lymphoma, and to explore the prognostic factors. Methods Between January 2000 and December 2008, 62 patients with nasal NK/T-cell lymphoma were treated with radiotherapy in our hospital. Their clinic data and efficiency were reviewed retrospectively. Kaplan-Meier methods were applied in unifactorial analysis and the COX regression model was applied in multivariate analysis. Results The median overall survival time was 69.7 months (95 % CI, 63.0-78.0 months), and 3, 5-year survival rate was 66.1% and 46.8 %. Metastasis was 61.8 % for the first reason which resulted in failure. The median survival time was 72.6 months in the increased group of numbers of T lymphocyte CD3 and 39.6 months in the decreased group, the difference was significant(x2 =4.9309, P =0.0264). Multivariate analysis confirmed that modified IPI 0-1 (x2 = 7.5266, P =0.0061), the numbers increased for CD3 (x2 =9.0912, P =0.0266), and complete remission(x2 = 9.0912, P =0.0106) were significant favorable prognostic factors for survival. Conclusion The radiotherapy was effective for patients with nasal NK/T-cell lymphoma, but was failure on account of distant metastasis, so systematic therapy still has an important role. modified IP1 0-1, the number increased for CD3 and complete remission were significant favorable prognostic factors for survival.
