Expression and clinical significance of antiapoptotic gene Aven in childhood acute lymphoblastic leukemia

VernacularTitle:抗凋亡基因Aven在儿童急性淋巴细胞白血病中的表达及其临床意义
Author: Yanrong WANG ; Runming JIN ; Jiawei XU ; Miao LIU
Publication Type:Journal Article
Keywords: Aven; Leukemia,lymphocytic,acute; Gene expression; Reverse transcriptase polymerase chain reaction
From: Journal of Leukemia & Lymphoma 2010;19(6):325-326,330
CountryChina
Language:Chinese
Abstract: Objective To explore the expression of antiapoptotic gene Aven in childhood acute lymphoblastic leukemia (ALL) and its relationship with clinical features of ALL. Methods Reverse transcriptase polymerase chain reaction (RT-PCR) was used to detect the expression of Aven mRNA in 55 cases of childhood ALL The control group included 11 childhood patients with no malignant hematological diseases. Results Aven mRNA expression was found to be higher in patients ≥10 years old and was also significantly higher in relapsed patients. Univariate and multivariate analysis indicated that Aven overexpression was an independent poor prognostic factor. Conclusion Aven mRNA expression is abnormal in childhood ALL and is an independent poor prognostic factor.