Effects of Hypertension and Pharmacological Intervention on the Left Ventricular Remodeling in Neuroendocrine Hypertensive Rats
10.3969/j.issn.0253-9896.2009.12.016
- VernacularTitle:高血压对大鼠心肌间质重构的影响及药物干预研究
- Author:
Wenjun JIA
;
Keqiang LIU
;
Xin QI
;
Songsong LI
;
Rongqing LI
- Publication Type:Journal Article
- Keywords:
hypertension procollagen collagen type Ⅲ tumor necrosis factor-alpha myocardium models;
animal rats;
Wistar
- From:
Tianjin Medical Journal
2009;37(12):1041-1044,彩2
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effect of medication on left ventricular myocardial matrix remodeling in neuroendocrine hypertensive rats and the mechanism and inhibitive method thereof. Methods: A neuroendocrine hypertensive model was established with adult Wistar rat. A total of 34 rats were randomly divided into four groups: parzosin (Hα), cilazapril (Hace), pentoxifylline(Hptx) and hypertensive control group(Hc). Ten normal-tensive Wistar rats were used as normal control (Nc). The systemic blood pressure, serum procollagen type Ⅲ level, serum TNF-α level, collagen volume fraction(CVF) were detected. Results: In Hace group, systolic pressure, left ventricular weight, the levels of serum procollagen type III and TNF-α were all reduced obviously compared to those in Hc group(P < 0.05). In Hα group, the systolic pressure and left ventricular weight were reduced obviously compared to those in Hc group(P < 0.05), however, the levels of serum procollagen type III and TNF-α were higher than those of Nc group(P < 0.05). In group Hptx, the systolic pressure and left ventricular weight were not decreased, while the levels of serum procollagen typeⅢ,TNF-α and CVF were reduced to normal levels. Conclusion:The angiotensin coverting enzyme inhibitor is the effective agent to reverse myocardial fibrosis, which can be achieved mostly by the inhibition of AngⅡ. Pentoxifylline may inhibit and reverse myocardial fibrosis which correlated with inhibiting TNF-α.
