Effects of loading dose of atorvastatin on inflammatory cytokines in acute myocardial infarction patients undergoing emergency percutaneous coronary intervention
10.3969/j.issn.0253-9896.2015.03.017
- VernacularTitle:围术期强化阿托伐他汀治疗对AMI患者急诊PCI术后Lp-PLA2及炎症因子的影响
- Author:
Rui SHAN
;
Shangqin WU
;
Aijuan CHENG
- Publication Type:Journal Article
- Keywords:
simvastatin;
myocardial infarction;
angioplasty,transluminal,percutaneous coronary;
phospholipases A2;
Atorvastatin
- From:
Tianjin Medical Journal
2015;(3):285-287,288
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of high loading dose of atorvastatin on lipoprotein-associated phospho?lipase A2 (Lp-PLA2) and inflammatory cytokines in patients with acute myocardial infarction (AMI), who underwent emergen?cy percutaneous coronary intervention (PCI). Methods A total of 65 cases with AMI who underwent emergency PCI be?tween October 2011 and August 2013 were randomly divided into two groups:control group (n=32, atorvastatin 20 mg/24 h) and high dose atorvastatin group (n=33, atorvastatin 40 mg/24 h). Two groups of patients were given the same basic treat?ment. Blood samples were obtained before treatment and 72 h after PCI in two groups. Levels of Lp-PLA2, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), alanine transaminase (ALT) and aspartate transaminase (AST) were detected in two groups. The adverse drug reactions were observed. Results There were no significant differences in Lp-PLA2, IL-6, TNF-α, ALT and AST levels between two groups (P>0.05). After PCI, the levels of Lp-PLA2, IL-6 and TNF-αwere significantly increased compared with those of baseline in two groups, and they were more notable in control group than those of high dose atorvastatin group (P<0.05). The levels of ALT and AST were also significantly higher after operation compared with those of basic levels (P<0.05), while there were no significant differences in ALT and AST after PCI between two groups (P>0.05). Conclusion The high loading dose of atorvastatin in AMI patients underwent emergency PCI can de?crease the inflammation and stabilize the plaques in acute stage, and which is safe.
