The Impact of Intermittent Hypoxia from Obstructive Sleep Apnea on Cardiovascular and Cerebrovascular Diseases
10.3969/j.issn.0253-9896.2014.09.028
- VernacularTitle:睡眠呼吸暂停模式间歇低氧对心脑血管的影响
- Author:
Miaomiao HAN
;
Qing HE
;
Yao SHI
;
Jing FENG
;
Baoyuan CHEN
- Publication Type:Journal Article
- Keywords:
sleep apnea,obstructive;
anoxia;
hypertension;
atherosclerosis;
coronary disease;
arrhythmias,cardiac;
stroke;
death,sudden;
heart failure;
review;
intermittent hypoxia
- From:
Tianjin Medical Journal
2014;(9):946-948,949
- CountryChina
- Language:Chinese
-
Abstract:
Obstructive sleep apnea (OSA) is characterized by repeated intermittent hypoxia (IH), hypercapnia, sleep fragmentation and intrathoracic pressure change. IH is related to the clinical pathophysiological processes of hypertension, atherosclerosis, coronary heart disease, arrhythmia, stroke, heart failure and sudden death. IH from OSA can lead to metabol-ic dysregulation, endothelial dysfunction, systemic inflammation, oxidative stress and the change of nerve body fluids, which has been shown to increase the risk of cardiovascular diseases. This study mainly describes the pathogenesis of IH leading to the various cardiovascular diseases.
