Research Progress on the Relationship between Metabolic Syndrome and Triple-Negative Breast Cancer
10.3969/j.issn.0253-9896.2014.09.030
- VernacularTitle:代谢综合征与三阴性乳腺癌关系的研究进展
- Author:
Yao TIAN
;
Yi WANG
;
Keyun ZHU
;
Baichuan WANG
;
Xuchen CAO
- Publication Type:Journal Article
- Keywords:
metabolic syndrome X;
breast neoplasms;
insulin;
leptin;
adiponectin;
insulin-like growth factor Ⅱ;
review;
triple-negative breast cancers
- From:
Tianjin Medical Journal
2014;(9):953-955,956
- CountryChina
- Language:Chinese
-
Abstract:
Metabolic syndrome (MS) and breast cancer are common diseases of women. Triple negative breast cancer (TNBCs) is one type of breast cancer, which is of much attention in recent years. Important components of MS include central obesity, high blood sugar, high triglycerides and low level of high-density lipoprotein (HDL-C), which increased the inci-dence risk of TNBCs. Common biomarkers of MS including insulin, adiponectin and leptin play an important role in the oc-currence and development of breast cancer, especially TNBCs. Insulin-like growth factor-IImRNA binding protein 3 (IMP3, an oncofetal protein) may be TNBCs’new invasive cancer biomarkers. In this paper, the research progress on the relation-ship between MS and TNBCs is reviewed.
