Clinical study on simplified intensity modulated radiotherapy plus TACE for treating primary hepatic cancer
10.3969/j.issn.1671-8348.2015.12.013
- VernacularTitle:简化调强放疗联合肝动脉化疗栓塞治疗原发性肝癌的临床研究
- Author:
Chuan ZHU
;
Deming XIONG
;
Xiangyi LI
;
Liangzhong LIU
;
Gang LI
;
Biyong REN
;
Qiang LIU
- Publication Type:Journal Article
- Keywords:
liver neoplasms;
radiotherapy;
intensity-modulated;
simplified intenstiy modulated radiation therapy;
radiation in-duced liver disease;
transcatheter arterial chemoembolization
- From:
Chongqing Medicine
2015;44(12):1626-1628,1632
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical curative effecand safety of ordinary intensity modulated and simplified intensi-ty modulated radiotherapy technique combined with transcathetearterial chemoembolization (TACE) fotreating primary hepaticancer(PHC) .MethodTotally 85 caseof Phwere randomly divided into the observation group (n=43) and the control group (n=42) .The observation group adopted the sequential therapy of TACE combined with the simplified intensity modulated radio-therapy(sIMRT) and the control group adopted the sequential therapy of TACE combined with the conventional intensity-modula-ted radiation therapy (cIMRT) .The shorterm curative effect,progresfree survival (PFS) ,overall survival (OS) ,and toxicity and adverse reactionwere observed in the two group.Result85 casewere followed up according to the requirement,2 casein the control group did noparticipated in the effecevaluation due to the unfinished radiotherapy projec.There were no statistically significandifferencebetween the two groupin the shorterm effect(55 .81% v.52 .50% ) ,PFS(25 .51 weekv.28 .06 weeks) and OS(78 .82 weekv.83 .22 weeks) (P＞0 .05) .The main toxicity and adverse reactionwere similain the two group,each i-tem had no statistical difference between the two group(P>0 .05) .Conclusion sIMRcan obtain the curative effecand progno-sisimilato cIMRwithouincreasing the toxicity and adverse reaction,and reducethe trend developing radioactive livedam-age ,which can be used athe routine replace mode of intensity modulated radiotherapy projecof PHC.
