Observation on effect of glucocorticoids combined with eradication of helicobacter pylori in treatment of idiopathic thrombocytopenic purpura
10.3969/j.issn.1671-8348.2015.12.019
- VernacularTitle:糖皮质激素联合根除幽门螺杆菌治疗IT P的疗效观察
- Author:
Hongyan MA
;
Liyun SHEN
;
Hongtao GONG
;
Hua YANG
- Publication Type:Journal Article
- Keywords:
purpura;
thrombocytopenic;
idiopathic;
glucocorticoids;
helicobacter pylori
- From:
Chongqing Medicine
2015;44(12):1643-1644,1647
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy of glucocorticoidcombined with the eradication of helicobactepylori (HP) in the treatmenof idiopathithrombocytopenipurpura(ITP) and itinfluence on platelecounand cell subset.MethodNinety-foucaseof ITP were randomly divided into two group.The control group(47 cases) wagiven prednisone treatmen, while the observation group(47 cases) wagiven prednisone combined with HP eradication treatmen.The clinical effecand recur-rence rate within 1 yeawere observed ,and the changeof platelecounand cell subsetwere tested .ResultThe total effective rate of the observation group wa89 .36% ,which wasignificantly highethan 70 .21% in the control group ;the 1-yearecurrence rate in the observation group wa36 .17% ,which wasignificantly lowethan 72 .34% in the control group ,the differencebetween the two grouphad statistical significance (P＜0 .05) .The platelecounaftetreatmenin the two groupwere significantly in-creased ,platelet-associated antibody(PAIgG) level wasignificantly decreased ,buthe improvemenin the observation group wamore significant(P＜0 .05) .The percentage of CD3+CD4+ % increased significantly ,the percentage of CD3+CD8+ % wadecreased significantly ,buthe improvemenin the observation group wamore obviou(P＜0 .05) .Conclusion Glucocorticoidcombined with HP eradication treatmenin treating ITP hadefinitely clinical efficacy ,can increase the platelecoun,improve cell subsetimbalance ,and iworthy to be clinically promoted .
