Expression and significance of Dkk-1 and Bcl-2 protein in sinonasal squamous cell carcinoma
10.3969/j.issn.1671-8348.2015.12.023
- VernacularTitle:Dkk-1及Bcl-2蛋白在人鼻腔鼻窦鳞状细胞癌中的表达及意义
- Author:
Honglue LU
;
Shujun ZHANG
;
Wenhui YUE
;
Fei KANG
;
Ran HAO
- Publication Type:Journal Article
- Keywords:
nasal cavity neoplasms;
paranasal sinus neoplasms;
neoplasms;
squamous cell;
Dickkopf-1;
B cell lymphoma/leu-kemia-2;
immunohistochemistry
- From:
Chongqing Medicine
2015;44(12):1652-1654,1657
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression and significance of Dickkopf-1 (Dkk-1) and cell lymphoma/leukemia-2 (Bcl-2) protein in sinonasal squamoucell carcinoma(SNSCC) .MethodThe immunohistochemical SP method and Western blomethod were adopted to determine the expression of Dkk-1 and Bcl-2 in 30 specimenof SNSC(SNSCgroup) ,38 specimenof sinonasal inverted papillomas(SNIP group) and 20 specimenof middle turbinate mucosa(control group) .ResultThe expression of DKK-1 protein in the SNSCgroup wasignificantly down-regulated compared with the SNIP group and the control group ,while the expression of Bcl-2 protein in the SNSCgroup wasignificantly up-regulated compared with the SNIP group and the control group;in the SNSCgroup ,the positive rateof DKK-1 protein and Bcl-2 protein in the high and middle differentiation group and the low differentiation group were 100 .00% ,68 .75% ,33 .33% and 50 .00% ,62 .50% ,100 .00% respectively ,the differencewere statistically significan(P＜0 .05) .Conclusion Dkk-1 protein may play an importanpromoting role in the developmenand pro-gression procesof SNSC,the expression of Dkk-1 protein hanegative correlation with the expression of Bcl-2 protein in SNSC,which may become new targespoof SNSCgene therapy .
