Study on correlation between the joint detection of CHE,AFU and AFP and primary liver cancer
10.3969/j.issn.1673-4130.2015.13.008
- VernacularTitle:联合检测 CHE、AFU 及 AFP 与原发性肝癌的相关性研究?
- Author:
Shaomei YU
;
Zhu LIN
;
Jufei LIAN
;
Weiqing ZHOU
;
Zhuo WANG
- Publication Type:Journal Article
- Keywords:
cholinesterase;
alpha-L-fucosidase;
alpha-fetoprotein;
primary hepatic cancer;
liver cirrhosis
- From:
International Journal of Laboratory Medicine
2015;(13):1821-1822,1825
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between the joint detection of cholinesterase(CHE),alpha-L-fucosidase(AFU) and alpha-fetoprotein(AFP)and primary hepatic cancer(PHC).Methods 56 cases of patients with PHC(PHC group),52 cases of patients with liver cirrhosis(LC group)and 60 cases of healthy individuals(control group)were enrolled in this study,and serum levels of CHE,AFU and AFP were detected and statistically analysed.Results Serum levels of CHE in patients with PHC were negatively correlated with levels of AFU and AFP(correlation coefficient was -0.889 and -0.797 respectively,P <0.05),the ser-um levels of CHE in patients with LC were also negatively correlated with levels of AFU and AFP (correlation coefficient was-0.598 and -0.653 respectively,P <0.05).The positive rates of joint detection of CHE,AFU and AFP in PHC group and LC group were higher than that in the control group,had statistically significant differences(P <0.05 ).Conclusion CHE,AFU and AFP are sensitive indicators of liver lesions,and the joint detection could provide reference value for diagnosis and monitoring pro-gression of PHC.
