Further study on clinical significance of hepatitis B virus core antibody
10.3969/j.issn.1673-4130.2015.13.014
- VernacularTitle:乙型肝炎病毒核心抗体临床意义再研究?
- Author:
Hankui ZHANG
;
Weijia WANG
;
Jianqiang LU
;
Manxing DU
;
Yanxiang LUO
;
Xiaoqian RUAN
;
Yanhua HUANG
;
Yanping FENG
- Publication Type:Journal Article
- Keywords:
hepatitis B virus core antibody;
chemiluminescence;
DNA;
virus
- From:
International Journal of Laboratory Medicine
2015;(13):1835-1836,1838
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyse clinical application of hepatitis B virus core antibody(HBcAb)detected by using the chemilu-minescence microparticle immunoassay.Methods A total of 1 6 830 specimen with positive HBcAb detected by using the two pairs of semi-hepatitis test from January 2012 to November 2014 were collected,and divided into three groups according to the cut off in-dex(COI)of detection results of HBcAb,including group 1.0-<9.0,group 9.0-<1 1.0 and group COI≥1 1.0,and detection re-sults were statistically analysed.The hepatitis B virus(HBV)DNA test was carried out in specimen with negative hepatitis B surface antigen(HBsAg)and hepatitis B surface antibody (HBsAb)and COI≥1 1.0.Results The detection rate of HBsAg(+)HBsAb(-) (13.84%)was significantly higher than other expression patterns in group ≥1 1.0(P <0.05).There was no statistically significant differences in positive rate among all expression patterns of HBsAg and HBsAb in the group 9.0-<1 1.0(P >0.05).The detec-tion rate of HBsAg(+)HBsAb(-)of group 9.0-<1 1.0 was significantly lower than that of the other two groups(P <0.05).A total of 304 specimen were HBsAg(-)HBsAb(-)and COI≥1 1,among them 64 specimen were HBV DNA postive and the posi-tive rate was 21.0%.Conclusion In the detection of HBcAb,COI≥1 1 and 1.0-<9.0 could be reference indicators for diagnosiing current and past HBV infection respectively,which should be combined with other laboratory indicators of HBV clinical data for comprehensive analysis.
