Diagnostic and therapeutic advances of high risk acute myeloid leukemia: reports from the 55th ASH annual meeting
10.3760/cma.j.issn.1009-9921.2014.03.001
- VernacularTitle:高危急性髓系白血病诊疗进展:第55届美国血液学会年会报道
- Author:
Ling PAN
;
Meng CHEN
;
Li ZHANG
- Publication Type:Journal Article
- Keywords:
Leukemia,acute,myeloid;
Molecular genetics;
Cytogenetics;
Risk stratification;
Diagnosis;
Therapy;
ASH annual meeting
- From:
Journal of Leukemia & Lymphoma
2014;23(3):129-132,136
- CountryChina
- Language:Chinese
-
Abstract:
Acute myeloid leukemia (AML) is a group of heterogeneous diseases with diverse genetic abnormalities,variable responsiveness to therapy and prognosis.In recent years,a lot of information has become available regarding chromosome and gene mutations that occur in AML and their influence on prognosis.Improvements in the understanding of molecular biology of AML are critical for accurate diagnosis.risk stratification,monitoring of minimal residual disease and provides opportunities to develop targeted therapies and improve the clinical outcome.This article reviewed chromosome abnormalities and characteristic gene mutations,and discussed their clinical signiflcances and presented new drugs in clinical trials presented in the 55th ASH annual meeting.
