Analysis of Clinicopathological Features and Prognosis of Gastric Carcinoma with Neuroendocrine Differentiation and Mixed Gonadal Neuroendocrine Carcinoma of the Stomach
10.3969/j.issn.0253-9896.2014.08.018
- VernacularTitle:胃癌伴神经内分泌分化和胃混合性腺神经内分泌癌临床病理及预后分析
- Author:
Wei SONG
;
Qingkai YU
- Publication Type:Journal Article
- Keywords:
stomach neoplasms;
carcinoma,neuroendocrine;
immunohistochemistry;
prognosis;
neuroendocrine dif-ferentiation;
mixed gonadal neuroendocrine carcinoma of the stomach
- From:
Tianjin Medical Journal
2014;(8):799-801,849
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical pathological features and prognosis of gastric carcinoma with neu-roendocrine differentiation (NED) and mixed gonadal neuroendocrine carcinoma of the stomach (MANECs). Methods A retrospective analysis of 61 cases of gastric carcinoma with NED and 34 cases of MANECs and their histochemistry and im-munohistochemistry were also observed. Prognosis of the 2 groups were compared by the Kaplan-Meiers survival analysis. Prognostic factors associated with patients with gastric cancer were analyzed by COX proportional hazards model. Results Tumor location, distant metastasis and lymph node metastasis were statistically different between these 2 groups (P<0.05). Syn positive expression rate is higher than CgA and CD56 in the gastric carcinoma with NED group;Postoperative survive pe-riod of the gastric carcinoma with NED is shorter than that of MANECs (P<0.05). Lymph node metastasis and distant region-al transfer is obviously correlated with prognosis (P<0.05). Conclusion Immunohistochemistry is important for the diag-nosis of these two tumor. The number of neuroendocrine cells can help to assess prognosis and guide treatment.
