The relationship and significance of serum TLR-4、TNF-α、IL-6 in neonates with preterm birth

VernacularTitle:TLR-4、TNF-α、IL-6与早产的关系及意义
Author: Huifang GU ; Xiaoping RONG ; Huangai ZHANG ; Chunping CHENG ; Xue LIU ; Shuxia GENG ; Xiang LIU ; Peng LIU ; Wei GUO
Publication Type:Journal Article
Keywords: TLR-4; TNF-α; IL-6; cytokine; preterm infant
From: Journal of Clinical Pediatrics 2014;(11):1039-1041,1047
CountryChina
Language:Chinese
Abstract: Objective To explore the roles of serum TLR-4, TNF-αand IL-6 in neonates with preterm birth. Methods A total of 120 neonates from neonatology department in the Xingtai People's Hospital were selected and divided into full-term group (n=40), premature rupture of fetal membranes (n=40) and idiopathic preterm group (n=40) based on the gestational age. The peripheral venous blood was collected within 30 minutes when the infants were born, and the supernatant was reserved after centrifuged. The levels of serum TLR-4, TNF-αand IL-6 were detected by enzyme-linked immunosorbent assay. Results The levels of TLR-4, TNF-αand IL-6 in idiopathic preterm and premature rupture of fetal membranes were signiifcantly higher than that in full-term group and showed positive correlation. Conclusion Cytokines TLR-4, TNF-αand IL-6 maybe closely related to the preterm birth.