Impact of domestic bivalirudin on platelet function during emergency percutaneous coronary interven-tion
10.3969/j.issn.1008-0074.2014.05.20
- VernacularTitle:国产比伐卢定在急诊介入治疗中对血小板功能的影响
- Author:
Yuping WANG
;
Jincheng GUO
;
Ming ZHANG
;
Haibin ZHANG
;
Xuekun ZHANG
;
Shunjin GAN
;
Guowang GAO
;
Lixin ZHANG
;
Zhenghai ZHANG
;
Yiting CAI
;
Yu TANG
;
Zijing LIU
- Publication Type:Journal Article
- Keywords:
Myocardial infarction;
Platelet aggregation;
Bivalirudin
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2014;23(5):544-545,546
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the impact of domestic bivalirudin on platelet function during emergency percutane-ous coronary intervention (PCI) .Methods :A total of 100 patients with acute ST segment elevation myocardial in-farction who recieved emergency PCI were randomly divided into unfractionated heparin group (UFH group ,n=53) and bivalirudin group (n=47) .Adenyl diphosphoric acid (ADP)-induced platelet aggregation rate was meas-ured and statistically compared between two groups before and after PCI .Results:Before emergency PCI ,there was no significant difference in ADP-induced platelet aggregation rate between two groups (P=0.99) .After emergency PCI ,ADP-induced platelet aggregation rate in bivalirudin group was significantly lower than that of UFH group [ (16.46 ± 10.23)% vs .(25.21 ± 15.91) % , P<0.01] .Conclusion:During percutaneous coronary intervention , compared with routine heparin anticoagulation , bivalirudin , as an anticoagulant , can more significantly inhibit platelet aggregation and possess antiplatelet effect .
