Research on effect of tirofiban on patients with ST-segment elevation acute coronary syndrome ;undergoing intervention treatment

VernacularTitle:替罗非班在ST段抬高型急性冠脉综合征介入治疗围手术期中的应用价值研究
Author: Rui DU
Publication Type:Journal Article
Keywords: Acute coronary syndrome; Intervention; Tirofiban
From: China Medical Equipment 2015;(1):101-103,104
CountryChina
Language:Chinese
Abstract: Objective: To analyze the effect of tirofiban on patients with ST-segment elevation acute coronary syndrome undergoing intervention treatment. Methods: Chosen patients with ST-segment elevation acute coronary syndrome between November 2012 to November 2013 as research subjects,randomly assigned to observed group received conventional treatment and control group received tirofiban perioperative, detecting before and after platelet CD40L expression, serum CRP levels, cardiovascular events. Results:1)After treatment, observed group patients platelet CD40L expression intensity was significantly lower than control group(t=3.281, P<0.05);2) at various time points after dosing, serum CRP in observation group were significantly lower than control group patients (t=2.183, t=2.748, t=4.719;P<0.05);3)After treatment, observation group patients cardiovascular event rate was significantly lower than control group(x2=6.493, P<0.05). Conclusion:Perioperative tirofiban therapy can effectively reduce the expression and inflammation in patients with platelet levels, reduce the incidence of adverse cardiovascular events, with positive clinical significance.