DTI study of corpus callosun for evaluating diffuse axonal injury

VernacularTitle:弥漫性轴索损伤的胼胝体DTI研究
Author: Hua LI ; Guihua ZHUANG ; Wenjun JI ; Yanhua GAO ; Yi CHEN ; Hao LIU ; Zhimin ZHU
Publication Type:Journal Article
Keywords: diffuse axonal injury; diffusion tensor imaging; the corpus callosum; magnetic resonance imaging
From: Journal of Practical Radiology 2015;(1):8-11,69
CountryChina
Language:Chinese
Abstract: Objective To evaluate DTI for early diagnosis and prognosis of diffuse axonal injury (DAI)in the moderate and sever traumatic brain injury (sTBI).Methods 30 patients with sTBI and 30 healthy controls were studied with T1 WI and DTI.The frac-tional anisotropy(FA)and ADC were quantified from different regions of interest(ROI)including the genu of corpus callosum(gCC), the trunk of CC,the splenium of CC(sCC)and the integrity CC.The FA and ADC of the same R0I was compared between TBI group and control group,and FA and ADC of the different parts of CC were compared in TBI group.Correlations between the FA or ADC and coma duration of the TBI patients were analyzed by Pearson linear correlation.Results Compared with control group,the FA value decreased significantly in each ROI,while ADC was reversed.The FA or ADC of the different ROI were correlated with co-ma duration in TBI group.Conclusion DTI is sensitive to detect the white matter injury of TBI.FA value detected in the CC can help diagnose DAI earlier and evaluate the degree of injury.