The curative effect of adefovir dipivoxil on Hepatitis B virus related primary hepatocellular carcinoma after comprehensive therapy
10.3969/j.issn.1002-1671.2014.11.032
- VernacularTitle:阿德福韦酯对乙型肝炎病毒相关性原发性肝癌综合治疗的疗效
- Author:
Yunfeng CHEN
- Publication Type:Journal Article
- Keywords:
Hepatitis B virus;
primary hepatocellular carcinoma;
adefovir dipivoxil
- From:
Journal of Practical Radiology
2014;(11):1894-1897,1901
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical therapeutic effect of adefovir dipivoxil on Hepatitis B virus related primary hepa-tocellular carcinoma after transcatheter hepatic arterical chemoembolization combined with radiofrequency ablation.Methods 30 pa-tients with Hepatitis B virus related primary hepatocellular carcinoma were randomly divided into study group and control group,1 5 cases in each group.All 30 patients were administrated comprehensive interventional therapy,while the study group took medicine of adefovir dipivoxil 10 mg/day additionally.Then all patients were followed up and evaluated the survival quality and mortality after operation.Results The high and medium quality survival rate were compared between two groups of patients in 48 weeks after oper-ation,and there was a significant difference (P <0.05).During 60 weeks,the high quality survival rate was different significantly (P <0.05).The mortality,and the medium quality were significantly different (P <0.05)during 72 weeks.while the difference was more significantly in the low quality survival (P <0.01).Furhtermore,the differences between the medium and low quality survival during 84 weeks and 2 years were also significantly different (P < 0.01 ).Conclusion Comprehensive interventional therapy com-bined with adefovir antiviral therapy can improve the survival quality and prolong the lifetime of patients who had Hepatitis B virus related primary hepatocellular carcinoma.
