Experimental and clinical study on overexpression of multidrug resistance proteins in the elderly acute myeloid leukemia
10.3760/cma.j.issn.1009-9921.2009.08.007
- VernacularTitle:老年人急性髓细胞白血病多药耐药蛋白过度表达的实验与临床研究
- Author:
Liping SU
;
Lingmei WU
;
Le LI
;
Li ZHANG
;
Yujin LU
;
Lei ZHU
;
Yongan ZHOU
- Publication Type:Journal Article
- Keywords:
Leukemia;
myeloid;
acute;
Elder;
P-glycoprotein;
Muhidrug resistance-associated protein
- From:
Journal of Leukemia & Lymphoma
2009;18(8):464-465,468
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of P-glycoprotein(P-gp), multidrug resistance-associated protein (MRP), lung resistance-related protein (LRP) and predicts treatment outcome in the elderly acute myeloid leukemia. Methods Multi-parameter flow eytometric assay was used to quantify expression of P-go, muhidrug-associated resistance protein (MRP) and lung resistance-related protein (LRP) in bone marrow viable blasts from 12 eldely acute myeloid leukemia patients at diagnosis (M2a:4, one is come from MDS, M3a:2, M5a:5, M6a:1). Correlation of the MDR protein expression with treatment outcome were analysed. Results The frequency of expression of P-gp, MRP and LRP was 58.33 %, 8.33 %, 50 %, respectively and P-gp(+)/MRP(+) 0, P-gp(+)/LRP(+) 33.33 %, MRP(+)/LRP(+) 0, P-gp(+)/MRP(+)/LRP(+)8.33 %, P-go(-)/MRP (-)/LRP(-) 33.33 %;respectively. The frequency of overexpression of P-gp or LRP alone and both of them were relatively higher. The rate of complete remission (CR) and overall survival (OS) at one year of P-gp(+) group were significantly lower than those of P-go(-) group, and LRP(+) group also were lower than LRP(-) group. Conclusion The Frequency of expression of P-gp or LRP and coexpression of both of them were higher in elderly patients with AML. The overexpression of P-gp and/or LRP was a poor prognotic factor for eldely myeloid leukemia in elderly patients.
