Hoechst 33342 and apoptosis
10.3760/cma.j.issn.1009-9921.2008.06.031
- VernacularTitle:荧光染料Hoechst 33342与细胞凋亡
- Author:
Yongling YIN
;
Xiulan SU
;
Zhen XIAO
- Publication Type:Journal Article
- Keywords:
Hoeehest 33342;
Apoptosis
- From:
Journal of Leukemia & Lymphoma
2008;17(6):476-479,481
- CountryChina
- Language:Chinese
-
Abstract:
Hoechst 33342 is a kind of fluorescent dye used for evaluating the cell cycle and apoptosis in a variety of benign and malignant cell lines,such as BC3H-1 monocytes,HI-60 cells,HT-144 melanoma cells and hepatoma cells.The inhibitor of topoisomerase I,the alternation of TATA box binding protein.the intraeellular accumulation of E2F-l protein and the mitochondrial dysfunction may play an important roles in the apoptosis pathway indueed bv Hoechst 33342.
