The Effect of Thalidomide and Triamcinolone Acetonide on Human Umbilical Vein Endothelial Cells
10.3969/j.issn.0253-9896.2009.12.014
- VernacularTitle:沙利度胺联合曲安奈德抑制人脐静脉内皮细胞增殖的研究
- Author:
Minwang MA
;
Song CHEN
;
Wenbo LI
- Publication Type:Journal Article
- Keywords:
endothelium;
vascular umbilical veins triamcinolone acetonide thalidomide cells;
cultured
- From:
Tianjin Medical Journal
2009;37(12):1035-1037,彩1
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effect of thalidomide and triamcinolone acetonide (TA) on human umbilical vein endothelial cells (HUVEC). Methods: The primary culture of HUVEC with collagenase Ⅰ was identified with FⅧAg. There were 3 groups in the study including thalidomide group(10, 25, 50 and 75 mg/L), TA and thalidomide group and control group. The absorbance ratio was measured through MTT-test. Results: Both thalidomide group and TA and thalidomide group showed inhibitor effect on the growth of HUVEC significantly(P < 0.01). The inhibitory effect was dose dependent. Compared to thalidomide group, the inhibitory effect was more significant in TA and thalidomide group(P < 0.05). Conclusion: Thalidomide can inhibit the growth of HUVEC; however, the effect was more significant in TA and thalidomide group.
