Study of IL-3 and other hematopoietic cytokines expression of human amnion-derived mesenchymal stem cells and its significance

VernacularTitle:多种造血细胞因子在人类羊膜间充质干细胞中表达的意义
Author: Chun YANG ; Jian YANG ; Mingxia SHI ; Zhi ZHOU ; Weijia LI
Publication Type:Journal Article
Keywords: Human amniotic-derived mesenchymal stem cells; Hematopoietic cell growth cytokines
From: Journal of Leukemia & Lymphoma 2010;19(12):732-734,738
CountryChina
Language:Chinese
Abstract: Objective To investigate the cytokine spectrum of cultured human amniotic-derived mesenchymal stem cells (A-MSC) for understanding its basis of molecular biology in hematopoietic in vitro.Methods Their hematopoietic cytokines expression was analyzed using RT-PCR in the mRNA level. Results It showed that in vitro subcultured human amniotic-derived mesenchymal stem cells were capable to express many important hematopoietic cytokines such as LIF, SCF, M-CSF, G-CSF, GM-CSF, IL-3, IL-6, IL-11 and so on. Conclusion Production of abundant of hematopoietic cytokines by human amniotic-derived mesenchymal stem cells may be effective for hematopoietic support and HSC transplantation.