The prognostic analysis for non-small cell lung cancer with brain metastases in 107 cases
10.3760/cma.j.issn.1006-9801.2015.03.007
- VernacularTitle:非小细胞肺癌脑转移患者107例预后分析
- Author:
Tao ZHANG
;
Yumin CHEN
;
Hao YANG
;
Jun KUANG
;
Ke HAN
- Publication Type:Journal Article
- Keywords:
Carcinoma,non-small cell lung;
Brain metastases;
Prognosis;
Factors
- From:
Cancer Research and Clinic
2015;27(3):168-170,174
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy of different treatments on non-small cell lung cancer (NSCLC) patients with brain metastases and to explore the influential factors of the prognosis.Methods The NSCLC patients with brain metastases treated from Jan.2010 to Dec.2011 were follow-up.The survival time and influences resulted from the treatments were analyzed.Results The average survive time of these patients was (11.93±5.53) months,and the median survive time was 11 months.The 6-month,1-year and 2-year overall survival rates were 90.7 ％,41.1％ and 6.4 ％,respectively.Multivariate analysis showed that control of extracranial lesions,Kamofsky score,target therapy and age were independent predictive factors of survival,and the OR value were 0.358 (95 ％ CI0.217-0.593),0.302 (95 ％ CI 0.182-0.502),0.170 (95 ％ CI 0.098-0.296) and 1.635 (95 ％ CI 1.010-2.647),respectively (all P ＜ 0.01).Conclusions Radiation therapy is an effective treatment on non-small cell lung cancer with brain metastases.Biological target therapy can effectively improve survival.The survival time also is correlated with age,Karnofsky score and control of extracranial lesions.
