Diagnostic value of combined examination of homocysteine and CEA for male patients with gastric cardia cancer

VernacularTitle:同型半胱氨酸、癌胚抗原联合检测对男性贲门癌患者的诊断价值
Author: Shuangping ZHANG ; Yun CHEN ; Cunzhi HAN ; Chunli WANG
Publication Type:Journal Article
Keywords: Gastric cardia neoplasms; Homocysteine; Tumor marker; CEA
From: Cancer Research and Clinic 2014;26(12):840-842,846
CountryChina
Language:Chinese
Abstract: Objective To investigate the diagnostic value of combined examination of homocysteine (Hcy) and CEA for male patients with gastric cardia cancer.Methods Serum concentration of Hcy,CEA,CA199,CA724,CA242 and TPS in 54 male patients with gastric cardia cancer and in 30 healthy men were measured.The diagnostic efficacy was analyzed between the combination of Hcy,CEA and the combination of Hcy,CEA,CA199,CA724,CA242,TPS.Results Total Hcy,CEA levels were significantly increased in patients group compared with control group ((20.3±9.2) μmol/L vs (13.7±3.1) μmol/L,(7.8±3.5) μg/L vs (1.6±1.2) μg/L,P ＜ 0.05).The sensitivity,specificity and accuracy of the combination of CEA,CA199,CA724,CA242 and TPS were 73.6 ％,64.5 ％ and 70.2 ％ respectively,while those of the combination of Hcy,CEA were 92.5 ％,64.5 ％ and 82.1％,respectively.There was significant difference between the combination of Hcy,CEA and the combination of CEA,CA199,CA724,CA242 and TPS (P ＜ 0.05).Conclusion Combined detection of Hcy and CEA is helpful for diagnosis in male patients with gastric cardia cancer.