The influence of different method of mediastinal lymph node excision on perioperative immune function of lung cancer patients
10.3760/cma.j.issn.1006-9801.2014.12.007
- VernacularTitle:不同纵隔淋巴结切除方式对非小细胞肺癌患者围手术期免疫功能的影响
- Author:
Zhiqiang ZHENG
;
Wenfeng ZHANG
;
Hong LIU
;
Zhenbo LIU
;
Shijie LI
;
Huaihao TANG
- Publication Type:Journal Article
- Keywords:
Lung neoplasms;
System lymph node dissection;
Lymph node sampling;
Immunity,cellular;
Immunosuppression
- From:
Cancer Research and Clinic
2014;26(12):816-819,826
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the influence of different method of mediastinal lymph node excision on the immune function of non-small cell lung cancer patients.Metbods Clinical data was collected continuously from 415 cases of inhospital patients with non-small cell lung cancer from March 2009 to March 2012,who were divided into system lymph node dissection group (SLND,216 cases) and lymph node sampling group (LNS,199 cases).The total lymphocytes,NK cells,CD4+ T cells and CD8+ T cells in blood samples taken preoperatively and at 3rd and 7th day postoperation were analyzed.Results Total lymphocytes,NK cells and CD8+ T cells were reduced significantly in the SLND group compared with those in LNS group at 3rd day and 7th day postoperation (3rd day:LC (0.95±0.57) × 109/L vs (1.10±0.65) × 109/L,CD8+ T cells (19.53± 6.48) ％ vs (20.93±6.70) ％,NK (17.36±6.06) ％ vs (18.57±5.97) ％,P ＜ 0.05; 7th day:LC (0.86±0.53) × 109/L vs (1.00±0.60) × 109/L,CD8+ T cells (17.27±5.64) ％ vs (18.40±5.26) ％,NK (13.11±4.84) ％ vs (14.20± 5.30) ％; P ＜ 0.05).CD4+ T cells in the SLND group were reduced significantly at 3rd day postoperation compared with LNS group ((29.59±6.53) ％ vs (31.19±6.32) ％,P ＜ 0.05).Conclusion LNS can reduce immunosuppression compared with SLND for postoperative patients.
