Curative evaluation of magnetic resonance spectroscopy on hepatic VX2 carcinoma implanted in rabbit after 5-Fu interventional thermochemotherapy
10.3760/cma.j.issn.1006-9801.2014.10.004
- VernacularTitle:磁共振波谱在5-氟尿嘧啶热化疗治疗兔肝VX2移植瘤效果评价中的应用
- Author:
Liang CHEN
;
Lipeng CHEN
;
Wenfeng LIU
;
Hongzhen WU
;
Lisha LAI
- Publication Type:Journal Article
- Keywords:
Carcinoma,hepatocellular;
Rabbits;
5-Fu;
Magnetic resonance spectroscopy
- From:
Cancer Research and Clinic
2014;26(10):663-666,669
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare magnetic resonance spectroscopy (MRS) characteristics and changes before and after 5-Fu interventional thermochemotherapy (ITC) as well as to analyze the correlation of Cho/Lip and apoptosis index (AI) in hepatic VX2 carcinoma animal model.Methods 20 rabbit models of hepatic VX2 carcinoma were implanted successfully.Ten days later,as tumor diameter≥ 10 mm,routine scan and 1H-MRS were performed before one day and after 14 days on all of rabbits by Philips 1.5T MR scanner.The changes of Cho peak,Lip peak and the ratio of Cho/Lip before and after the treatment were analyzed.Specimens of AI were examined and compared with the ratio of Cho/Lip.Results The Cho peak and Lip peak were increased before ITC.After ITC,the Cho peak and the ratio of Cho/Lip decreased than before.The Lip peak was further increased than that of before.AI was correlated negatively with the ratio of Cho/Lip (r =-0.56,P =0.02).Conclusions The metabolites of different ROI are matched with the levels and scopes of AI.1H-MRS can be used to evaluate tumor cell apoptosis and energy metabolism changes of the rabbit models of hepatic VX2 carcinoma with the treatment.
