Analysis of domestic literature of 135 cases of chronic neutrophilic leukemia
10.3760/cma.j.issn.1009-9921.2009.06.008
- VernacularTitle:慢性中性粒细胞白血病国内文献135例分析
- Author:
Jun XUE
- Publication Type:Journal Article
- Keywords:
Leukemia,myeloid,chronic;
Myeloproliferative disease;
Genes,abl
- From:
Journal of Leukemia & Lymphoma
2009;18(6):345-346,349
- CountryChina
- Language:Chinese
-
Abstract:
Objective To summarize clinical data of chronic neutrophilic leukemia(CNL) in China.Methods Chronic neutrophilic leukemia was searched as key words in full text database of Chinese periodical(www. cnki. net)(from 1994 to 2008). Results 136 cases of CNL were found, including male 77 cases and female 59 cases. Male: female ratio was 1.305:1. The mean age was 57.8 (8 ～87) years old. The common symptoms was fatigue,granulocytosis and upper abdominal discomfort or tumour. The splenomegaly was found in the majority of cases. The mature neutrophilic granulocyte in peripheral blood was high and cast longer time with raised segmented and band staged of neutrophils. Serum assay showed a raised level of VitB12 and uric acid. Bone marrow aspirate showed a hypercellular marrow with marked granulocytic proliferation, consisting mainly of stab forms and segmented neutrophils. The NAP score was high. Both Ph chromosome and bcr-abl fusion gene was negtive. Conclusion CNL was a scarce chronic leukemia. It should be discriminated with leukemoid reaction and chronic granulocytic leukemia. The course of CNL patients was long or short. It could transform into acute leukemia and palliative therapy was mainly applied at present.
