Inductive chemotherapy with low-dose CHG stimulating regimen in elderly acute myeloid leukemia
10.3760/cma.j.issn.1009-9921.2010.06.009
- VernacularTitle:小剂量CHG预激方案治疗老年人急性髓系白血病的临床研究
- Author:
Jiaqiang LIU
;
Jing LENG
;
Lei SANG
;
Tongying LI
- Publication Type:Journal Article
- Keywords:
Leukemia;
Aged;
Granulocyte colony-stimulating factor;
Homoharringtonine;
Cytarabine;
Low-dose
- From:
Journal of Leukemia & Lymphoma
2010;19(6):347-348,351
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the efficacy and side effect of inductive chemotherapy with lowdose,cytarabine,homoharringtonine and granulocyte colony-stimulating factor(CHG) in elderly acute myeloid leukemia(AML). Methods Thirty-five elderly patients (age＞60 years) with AML were enrolled for the initial treatment with CHG regimen,The CHG regimen consisted of cytarabine 10 mg/m2 per 12 h by subcutaneous injection,days 1-14,homoharringtonine 1 mg/m2 per day by intravenous continuous infusion,days 1-14,and G-CSF 200 μg/m2 per day by subcutaneous injection 12 h before chemotherapy,days 0-14. G-CSF only was used when white blood cell count(WBC) was less than 20×109/L during the whole course. Results After the first course,12 patients achieved complete response (CR),15 patients achieved partial response(PR),and 8 patients had no response(NR). After the second course,5 of 15 PR patients achieved CR,2 of 8 NR patients achieved PR. The total effective rate was 82 % (29/35). Of those 17 CR patients,eleven patients continued maintenance therapy and remained in remission for 12-34 months with a median CR duration of 18 months,the other 6 patients relapsed and were treated with original regimen,including one achieved CR again,4 achieved PR,and 1 achieved NR. The CHG regimen had mild hematologic toxicities and no severe nonhematologic toxicities. Conclusion CHG regimen is effective and well tolerated in remission for elderly AML.
