Expression of NF-κB p50 subunit in nodal peripheral T-cell lymphoma-uuspecified

Yinan Wang; Hongmin LI; Yu Zhao; Weidong Liu; Shoudong MA; Haishu Yue

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Expression of NF-κB p50 subunit in nodal peripheral T-cell lymphoma-uuspecified

VernacularTitle:NF-κB p50亚基在原发结内的非特指型外周T细胞淋巴瘤中的表达
Author: Yinan WANG ; Hongmin LI ; Yu ZHAO ; Weidong LIU ; Shoudong MA ; Haishu YUE
Publication Type:Journal Article
Keywords: Lymphoma,T-cell,peripheral; NF-κB p50 subunit; P-glycoprotein; Ki-67 antigen; Immunohistochemistry; Prognosis
From: Journal of Leukemia & Lymphoma 2009;18(3):149-151,154
CountryChina
Language:Chinese
Abstract: Objective To study the expression of NF-κB p50 in nodal peripheral T-cell lymphomasunspecified (PTCL-U),and investigated the relationship between NF-κB and PTCL-U's complex biological behavior. Methods 51 patients with nodal PTCL-U were analysed by detecting the expression of NF-κB p50, p170 by immunohistochemistry and correlation between them and PTCL-U' s clinical feature, treatment effectiveness and prognosis were also studied. Results 11 patients(21.6 %, 11/51) and 31patients (60.8 %,31/51) were respectively positive for N F-κB p50 and p 170 expression. Expression of NF-κB were significantly correlated with p170 expression, poor performance status (PS＞2) and non-complete remission in first line treatment(Spearman correlation= 0.459, 0.313, 0.284; P = 0.001, 0.025, 0.044). Overall survival rate of NFκB p50-positive PTCL-U was significantly lower than that of NF-κB p50-negative patients by Log-Rank test (P =0.0451). Multivariate analysis showed poor performance and higher Ki-67 were independent prognostic factor for PTCL-U, while NF-κB p50 was not. Conclusion The expression of NF-κB pS0 was correlated with muhidrug resistance and poor prognosis in nodal PTCL-U.